In situ investigations on enzymatic degradation of poly

SPR Bionavis

Q-Sense 4 sample in one Run workhorse

The present study leads to the following conclusion. QCM-D

and SPR can be used to investigate the enzymatic degradation of

a polymer film in real time, where the changes in mass and morphology

of the film can be well described by the frequency and

dissipation in QCM-D as well as the SPR signal response. PCL

with small crystallites degrades in a way of layer-by-layer with

pseudo first-order degradation kinetics. The degradation of PCL

with crystalline lamellae exhibits two-stage kinetics, which relates

to the degradation of amorphous PCL and PCL crystallites,

respectively. The former degrades more quickly than the latter,

leading the film to be microporous