QCM-D Technology
By collecting both the dissipation and the resonance frequency of a quartz crystal,
QCM-D technology can be used to characterize the formation of thin films (nm) such as proteins, polymers and cells onto surfaces, in liquid. This is QCM-D, Quartz Crystal Microbalance with Dissipation monitoring, Q-Sense's proprietary sensor technology.
In liquid, an adsorbed film may consist of a considerably high amount of water, which is sensed as a mass uptake by all QCMs. By measuring several frequencies and the dissipation it becomes possible to determine whether the adsorbed film is rigid or water-rich (soft) which is not possible by looking only at the frequency response. The amount of water in an adsorbed film can be as high as 95% depending on the kind of molecule and the type of surface you are studying. Picture elongated molecules - if they would adsorb flat on the surface, little water will be coupled to the molecules. However, if they adsorb standing up at the surface, lots of water will be coupled. With QCM-D the kinetics of both structural changes and mass changes are obtained simultaneously.
QCM-D technology can be used to characterize the formation of thin films (nm) such as proteins, polymers and cells onto surfaces, in liquid. This is QCM-D, Quartz Crystal Microbalance with Dissipation monitoring, Q-Sense's proprietary sensor technology.
In liquid, an adsorbed film may consist of a considerably high amount of water, which is sensed as a mass uptake by all QCMs. By measuring several frequencies and the dissipation it becomes possible to determine whether the adsorbed film is rigid or water-rich (soft) which is not possible by looking only at the frequency response. The amount of water in an adsorbed film can be as high as 95% depending on the kind of molecule and the type of surface you are studying. Picture elongated molecules - if they would adsorb flat on the surface, little water will be coupled to the molecules. However, if they adsorb standing up at the surface, lots of water will be coupled. With QCM-D the kinetics of both structural changes and mass changes are obtained simultaneously.
Would you like to ask specific questions or gain more information about the QCM-D technique? You are welcome to contact us at any time.
The QCM-D Principle
Unlike all other QCMs, QCM-D monitors the response of the freely oscillating crystal, which is faster and more accurate than the usual frequency sweep principle.
Unlike all other QCMs, QCM-D monitors the response of the freely oscillating crystal, which is faster and more accurate than the usual frequency sweep principle.
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